Study findings have identified a new mechanism of circadian regulation of the blood-brain barrier (BBB) in Drosophila that makes drugs targeted to the brain more effective when administered at night. The BBB is a highly selective membrane barrier with tight junctions that only allows certain molecules to pass through and prevents harmful toxins and bacteria from reaching the brain. However, this strict gatekeeping can prevent medications from effectively treating brain-related disorders, such as epilepsy. The study was published in Cell. More read.